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Melville lies directly east of the boundary with Nassau County. The Long Island Expressway (LIE) and Northern State Parkway, two of the country’s busiest highways and major points of entry in and out of New York City, pass through Melville. Melville is located immediately off Exit 49 of the LIE. New York State Route 110 runs through the center of Melville.

Melville is home to the U.S. headquarters of several national and international corporations, including Canon USA, Hain Celestial, Arrow Electronics, Chyron, MSC Industrial Direct, Nikon, OSI Pharmaceuticals, Allion the medical and dental supply distributor Henry Schein, Bouchard Transportation and global staffing giant Adecco (US headquarters). In addition, significant operations of Manhattan-based Estée Lauder are conducted there. Melville is also the host of operations for many Fortune 500 companies. These headquarters and many other corporate and industrial centers are found on or near Route 110, which runs north to south through Huntington, Melville, Farmingdale, North Amityville, and http://FarmingdaleAmityville. [Wikipedia]